Carlsson, Emil, Cowell-McGlory, Taylor and Hedrich, Christian M ORCID: 0000-0002-1295-6179
(2023)
cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases.
IMMUNOLOGY, 170 (4).
pp. 470-482.
Abstract
T lymphocytes play a crucial role in adaptive immunity. Dysregulation of T cell-derived inflammatory cytokine expression and loss of self-tolerance promote inflammation and tissue damage in several autoimmune/inflammatory diseases, including systemic lupus erythematosus (SLE) and psoriasis. The transcription factor cAMP responsive element modulator α (CREMα) plays a key role in the regulation of T cell homeostasis. Increased expression of CREMα is a hallmark of the T cell-mediated inflammatory diseases SLE and psoriasis. Notably, CREMα regulates the expression of effector molecules through trans-regulation and/or the co-recruitment of epigenetic modifiers, including DNA methyltransferases (DNMT3a), histone-methyltransferases (G9a) and histone acetyltransferases (p300). Thus, CREMα may be used as a biomarker for disease activity and/or target for future targeted therapeutic interventions.
Item Type: | Article |
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Uncontrolled Keywords: | CREM, epigenetics, lymphocyte, psoriasis, psoriatic arthritis, systemic lupus erythematosus |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 28 Jul 2023 13:53 |
Last Modified: | 10 Nov 2023 10:45 |
DOI: | 10.1111/imm.13680 |
Open Access URL: | https://doi.org/10.1111/imm.13680 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171973 |