Kenny, Louise C ORCID: 0000-0002-9011-759X, Brown, Leslie W, Ortea, Paloma, Tuytten, Robin and Kell, Douglas B ORCID: 0000-0001-5838-7963
(2023)
Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia.
BIOSCIENCE REPORTS, 43 (7).
BSR20230160-.
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Abstract
Ergothioneine, an antioxidant nutraceutical mainly at present derived from the dietary intake of mushrooms, has been suggested as a preventive for pre-eclampsia (PE). We analysed early pregnancy samples from a cohort of 432 first time mothers as part of the Screening for Endpoints in Pregnancy (SCOPE, European branch) project to determine the concentration of ergothioneine in their plasma. There was a weak association between the ergothioneine levels and maternal age but none for BMI. Of these 432 women, 97 went on to develop pre-term (23) or term (74) PE. If a threshold was set at the 90th percentile of the reference range in the control population (≥462 ng/ml), only one of these 97 women (1%) developed PE, versus 96/397 (24.2%) whose ergothioneine level was below this threshold. One possible interpretation of these findings, consistent with previous experiments in a reduced uterine perfusion model in rats, is that ergothioneine may indeed prove protective against PE in humans. An intervention study of some kind now seems warranted.
Item Type: | Article |
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Uncontrolled Keywords: | SCOPE Consortium, Uterus, Animals, Humans, Rats, Pre-Eclampsia, Ergothioneine, Antioxidants, Pregnancy, Dietary Supplements, Female, Biomarkers |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
Depositing User: | Symplectic Admin |
Date Deposited: | 09 Aug 2023 14:23 |
Last Modified: | 19 Oct 2023 08:40 |
DOI: | 10.1042/BSR20230160 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3172120 |