Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia

Kenny, Louise C ORCID: 0000-0002-9011-759X, Brown, Leslie W, Ortea, Paloma, Tuytten, Robin and Kell, Douglas B ORCID: 0000-0001-5838-7963 (2023) Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia. BIOSCIENCE REPORTS, 43 (7). BSR20230160-.

PDF
Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia.pdf - Open Access published version
Download (1MB) | Preview

Official URL: http://dx.doi.org/10.1042/bsr20230160

Abstract

Ergothioneine, an antioxidant nutraceutical mainly at present derived from the dietary intake of mushrooms, has been suggested as a preventive for pre-eclampsia (PE). We analysed early pregnancy samples from a cohort of 432 first time mothers as part of the Screening for Endpoints in Pregnancy (SCOPE, European branch) project to determine the concentration of ergothioneine in their plasma. There was a weak association between the ergothioneine levels and maternal age but none for BMI. Of these 432 women, 97 went on to develop pre-term (23) or term (74) PE. If a threshold was set at the 90th percentile of the reference range in the control population (≥462 ng/ml), only one of these 97 women (1%) developed PE, versus 96/397 (24.2%) whose ergothioneine level was below this threshold. One possible interpretation of these findings, consistent with previous experiments in a reduced uterine perfusion model in rats, is that ergothioneine may indeed prove protective against PE in humans. An intervention study of some kind now seems warranted.

Item Type:	Article
Uncontrolled Keywords:	SCOPE Consortium, Uterus, Animals, Humans, Rats, Pre-Eclampsia, Ergothioneine, Antioxidants, Pregnancy, Dietary Supplements, Female, Biomarkers
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	09 Aug 2023 14:23
Last Modified:	19 Oct 2023 08:40
DOI:	10.1042/BSR20230160
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172120