Prevalence, Temporal Course and Risk Factors for Phantom Eye Symptoms in Uveal Melanoma

Brown, Stephen ORCID: 0000-0002-6142-0995, Hope-Stone, Laura ORCID: 0000-0001-6069-7231, Hussain, Rumana ORCID: 0000-0001-8208-5009, Heimann, Heinrich, van der Voort, Nicola and Cherry, Mary (2023) Prevalence, Temporal Course and Risk Factors for Phantom Eye Symptoms in Uveal Melanoma. Eye, 38 (4). pp. 707-713.

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Abstract

Background Phantom eye symptoms (PES), particularly phantom visual sensations (PVS) and phantom eye pain (PEP), are common in enucleated patients and can lead to psychological distress. Current cross-sectional studies cannot examine the temporal course of symptoms, nor can they identify dynamic risk factors or consequences of PES. Methods Cohort study of 105 enucleated uveal melanoma patients returning self-report questionnaires, within 4 weeks of diagnosis and 6-, 12- and 24-months post-treatment. Questionnaires measuring PVS and PEP symptoms in the week prior to completion, pain severity, Hospital Anxiety and Depression Scale scores and the Functional Assessment of Cancer Therapy scale (FACT-G) measuring quality of life. Results PVS and PEP emerged after 6 months, were relatively stable over the study and did not remit. PVS showed 6-, 12- and 24-month prevalence rates of 44.6%, 48.2% and 30.2%, and PEP 16.1%, 18.4% and 17.5% respectively. PVS were generally elementary, with only 10–15% of the total cohort experiencing complex sensations. PEP was generally neither prolonged nor intense, except in a small proportion. PVS and PEP were showed moderate associations but did not predict each other prospectively. Anxiety within 4 weeks of diagnosis was a risk factor for the initiation of PEP. Neither PVS nor PEP prospectively predicted anxiety, depression or quality of life. Conclusions PES were prevalent and non-remitting, beginning within 6 months of enucleation. PVS and PEP may not represent symptoms of a coherent syndrome. We discuss findings with reference to theories of phantom sensations, and directions for clinical practise and research.

Item Type:	Article
Uncontrolled Keywords:	Humans, Melanoma, Uveal Neoplasms, Eye Diseases, Prevalence, Risk Factors, Cohort Studies, Cross-Sectional Studies, Quality of Life
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	31 Aug 2023 15:38
Last Modified:	15 Mar 2024 13:36
DOI:	10.1038/s41433-023-02756-w
Open Access URL:	https://doi.org/10.1038/s41433-023-02756-w
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172455