Laser-cutting: A novel alternative approach for point-of-care manufacturing of bespoke tablets.

Liu, Yujing, M Leonova, Anna, Royall, Paul G ORCID: 0000-0002-7101-2776, Abdillah Akbar, Bambang VEB, Cao, Zhengge, Jones, Stuart A, Isreb, Abdullah, Hawcutt, Daniel B ORCID: 0000-0002-8120-6507 and Alhnan, Mohamed A (2023) Laser-cutting: A novel alternative approach for point-of-care manufacturing of bespoke tablets. International journal of pharmaceutics, 647. 123518-.

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Official URL: http://dx.doi.org/10.1016/j.ijpharm.2023.123518

Abstract

A novel subtractive manufacturing method to produce bespoke tablets with immediate and extended drug release is presented. This is the first report on applying fusion laser cutting to produce bespoke furosemide solid dosage forms based on pharmaceutical-grade polymeric carriers. Cylindric tablets of different sizes were produced by controlling the two-dimensional design of circles of the corresponding diameter. Immediate and extended drug release patterns were achieved by modifying the composition of the polymeric matrix. Thermal analysis and XRD indicated that furosemide was present in an amorphous form. The laser-cut tablets demonstrated no significant drug degradation (<2%) nor the formation of impurities were identified. Multi-linear regression was used to quantify the influences of laser-cutting process parameters (laser energy levels, scan speeds, and the number of laser applications) on the depth of the laser cut. The utility of this approach was exemplified by manufacturing tablets of accurate doses of furosemide. Unlike additive or formative manufacturing, the reported approach of subtractive manufacturing avoids the modification of the structure, e.g., the physical form of the drug or matrix density of the tablet during the production process. Hence, fusion laser cutting is less likely to modify critical quality attributes such as release patterns or drug contents. In a point-of-care manufacturing scenario, laser cutting offers a significant advantage of simplifying quality control and a real-time release of laser-cut products such as solid dosage forms and implants.

Item Type:	Article
Uncontrolled Keywords:	Furosemide, Polymers, Tablets, Technology, Pharmaceutical, Point-of-Care Systems, Drug Liberation, Printing, Three-Dimensional
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Nov 2023 16:44
Last Modified:	24 Nov 2023 12:59
DOI:	10.1016/j.ijpharm.2023.123518
Open Access URL:	https://doi.org/10.1016/j.ijpharm.2023.123518
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176616