Thrombocytopaenia in antiphospholipid syndrome: a free radical perspective

Ames, Paul RJ, Bucci, Tommaso ORCID: 0000-0003-2895-6234, Merashli, Mira, Arcaro, Alessia and Gentile, Fabrizio (2023) Thrombocytopaenia in antiphospholipid syndrome: a free radical perspective. RHEUMATOLOGY, 62 (6). pp. 2070-2075.

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Abstract

Thrombosis associated with thrombocytopaenia is an apparent paradox that is present across a wide spectrum of disorders. While thrombocytopaenia has been a controversial clinical classification criterion for APS, as initial reports failed to demonstrate a relation between low platelet count with other clinical or laboratory manifestations of the syndrome, recent data highlight the association between mild-moderate thrombocytopaenia and the risk of thrombosis. Although aPL antibodies may induce platelet activation in vitro, additional stimuli may contribute to their activation in vivo, among which are reactive oxygen and nitrogen species and lipid peroxidation products, which are elevated in patients with APS; an excess of the same stimuli may induce megakaryocyte and platelet apoptosis that leads to decreased platelet production and increased destruction, resulting ultimately in thrombocytopaenia. Herein we provide a novel plausible framework involving free radicals that could add to the understanding of the thrombocytopaenia-thrombosis paradox in APS.

Item Type:	Article
Uncontrolled Keywords:	thrombocytopaenia, APS, reactive oxygen and nitrogen species, lipid peroxidation products
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Mar 2024 08:19
Last Modified:	01 Mar 2024 08:19
DOI:	10.1093/rheumatology/keac650
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179013