Talin as a mechanosensitive signaling hub.

Goult, Benjamin T ORCID: 0000-0002-3438-2807, Yan, Jie and Schwartz, Martin A ORCID: 0000-0002-2071-1243 (2018) Talin as a mechanosensitive signaling hub. The Journal of cell biology, 217 (11). pp. 3776-3784.

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Abstract

Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical features of the ECM. Talin is a cytoplasmic protein consisting of a globular head domain and a series of α-helical bundles that form its long rod domain. Talin binds to the cytoplasmic domain of integrin β-subunits, activates integrins, couples them to the actin cytoskeleton, and regulates integrin signaling. Recent evidence suggests switch-like behavior of the helix bundles that make up the talin rod domains, where individual domains open at different tension levels, exerting positive or negative effects on different protein interactions. These results lead us to propose that talin functions as a mechanosensitive signaling hub that integrates multiple extracellular and intracellular inputs to define a major axis of adhesion signaling.

Item Type:	Article
Uncontrolled Keywords:	Extracellular Matrix, Animals, Humans, Talin, Integrins, Mechanotransduction, Cellular, Protein Structure, Secondary, Protein Domains
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	13 Mar 2024 09:56
Last Modified:	13 Mar 2024 09:56
DOI:	10.1083/jcb.201808061
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179318