Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force.

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Smith, EMD ORCID: 0000-0002-8371-7597, Aggarwal, A, Ainsworth, J, Al-Abadi, E, Avcin, T, Bortey, L, Burnham, J, Ciurtin, C, Hedrich, CM ORCID: 0000-0002-1295-6179, Kamphuis, S et al (show 18 more authors) , Lambert, L, Levy, DM, Lewandowski, L, Maxwell, N, Morand, E, Özen, S, Pain, CE ORCID: 0000-0003-4965-3259, Ravelli, A, Saad Magalhaes, C, Pilkington, C, Schonenberg-Meinema, D, Scott, C, Tullus, K, Beresford, MW, Goilav, B, Goss, N, Oni, L ORCID: 0000-0002-1532-2390 and Marks, SD (2024) Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force. Clinical immunology (Orlando, Fla.), 263. p. 110214.

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Abstract

<h4>Objective</h4>To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice.<h4>Methods</h4>The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria.<h4>Results</h4>The Task Force proposed two definitions of remission: 'cSLE clinical remission on steroids (cCR)' and 'cSLE clinical remission off steroids (cCR-0)'. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0-3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero.<h4>Conclusions</h4>cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.

Item Type:	Article
Uncontrolled Keywords:	Childhood-onset SLE, Remission, T2T, Treat-to-target, cSLE
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	19 Apr 2024 08:17
Last Modified:	04 May 2024 08:45
DOI:	10.1016/j.clim.2024.110214
Open Access URL:	https://doi.org/10.1016/j.clim.2024.110214
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180447