Smith, EMD ORCID: 0000-0002-8371-7597, Aggarwal, A, Ainsworth, J, Al-Abadi, E, Avcin, T, Bortey, L, Burnham, J, Ciurtin, C, Hedrich, CM ORCID: 0000-0002-1295-6179, Kamphuis, S et al (show 18 more authors)
(2024)
Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force.
Clinical immunology (Orlando, Fla.), 263.
p. 110214.
Abstract
<h4>Objective</h4>To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice.<h4>Methods</h4>The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria.<h4>Results</h4>The Task Force proposed two definitions of remission: 'cSLE clinical remission on steroids (cCR)' and 'cSLE clinical remission off steroids (cCR-0)'. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0-3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero.<h4>Conclusions</h4>cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.
Item Type: | Article |
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Uncontrolled Keywords: | Childhood-onset SLE, Remission, T2T, Treat-to-target, cSLE |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 19 Apr 2024 08:17 |
Last Modified: | 04 May 2024 08:45 |
DOI: | 10.1016/j.clim.2024.110214 |
Open Access URL: | https://doi.org/10.1016/j.clim.2024.110214 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3180447 |