RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes



McDermott, B, Ellis, S, Bou-Gharios, G ORCID: 0000-0002-9563-9418, Clegg, P ORCID: 0000-0003-0632-0032 and Tew, S ORCID: 0000-0002-1213-5418
(2016) RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis and Cartilage, 24 (7). 1263 - 1273.

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Abstract

This study demonstrates for the first time how RNABPs are able to affect the balance of anabolic and catabolic gene expression in human chondrocytes. The post-transcriptional mechanisms controlled by RNABPs present novel avenues of regulation and potential points of intervention for controlling the expression of SOX9 and MMP13 in chondrocytes.

Item Type: Article
Uncontrolled Keywords: Chondrocyte, mRNA, SOX9, MMP13
Depositing User: Symplectic Admin
Date Deposited: 05 Apr 2016 15:41
Last Modified: 27 Nov 2021 00:10
DOI: 10.1016/j.joca.2016.01.988
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3000024