Damon, Deidre E, Maher, Yosef S, Yin, Mengzhen, Jjunju, Fred PM 
ORCID: 0000-0001-6257-434X, Young, Iain S ORCID: 0000-0002-9502-6216, Taylor, Stephen ORCID: 0000-0002-2144-8459, Maher, Simon and Badu-Tawiah, Abraham K
(2016)
2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization.
ANALYST, 141 (12).
pp. 3866-3873.
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Manuscript_wax-printed PS-MS_Revised_Final.docx - Author Accepted Manuscript Download (3MB) |
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Abstract
Paper-based microfluidic channels were created from solid wax printing, and the resultant 2D wax-printed paper substrates were used for paper spray (PS) mass spectrometry (MS) analysis of small organic compounds. Controlling fluid flow at the tip of the wax-printed paper triangles enabled the use of lower spray voltages (0.5–1 kV) and extended signal lifetime (10 minutes) in PS-MS. High sensitivity (sub ng mL−1 levels) and quantitation precision (<10% RSD) have been achieved in the analysis of illicit drugs in 4 μL of raw urine (fresh and dry), as well as corrosion inhibitors and pesticides in water samples. The reported study encourages the future development of disposable 3D microfluidic paper-based analytical devices, which function with simple operation but capable of on-chip analyte detection by MS; such a device can replace the traditional complex laboratory procedures for MS analysis to enable on-site in situ sampling with portable mass spectrometers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Bioengineering, Biotechnology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Jun 2016 09:24 |
| Last Modified: | 25 Apr 2024 21:19 |
| DOI: | 10.1039/c6an00168h |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3001751 |
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