On the heterogeneity of human populations as reflected by mortality dynamics

Avraam, Demetris ORCID: 0000-0001-8908-2441, Arnold, Severine, Vasieva, Olga and Vasiev, Bakhtier ORCID: 0000-0002-3452-7885 (2016) On the heterogeneity of human populations as reflected by mortality dynamics. AGING-US, 8 (11). pp. 3045-3064.

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Abstract

The heterogeneity of populations is used to explain the variability of mortality rates across the lifespan and their deviations from an exponential growth at young and very old ages. A mathematical model that combines the heterogeneity with the assumption that the mortality of each constituent subpopulation increases exponentially with age, has been shown to successfully reproduce the entire mortality pattern across the lifespan and its evolution over time. In this work we aim to show that the heterogeneity is not only a convenient consideration for fitting mortality data but is indeed the actual structure of the population as reflected by the mortality dynamics over age and time. In particular, we show that the model of heterogeneous population fits mortality data better than other commonly used mortality models. This was demonstrated using cohort data taken for the entire lifespan as well as for only old ages. Also, we show that the model can reproduce seemingly contradicting observations in late-life mortality dynamics. Finally, we show that the homogenisation of a population, observed by fitting the model to actual data of consecutive periods, can be associated with the evolution of allele frequencies if the heterogeneity is assumed to reflect the genetic variations within the population.

Item Type:	Article
Uncontrolled Keywords:	mortality dynamics, mathematical modeling, model fitting, demography, population genetics
Depositing User:	Symplectic Admin
Date Deposited:	11 Jan 2017 11:11
Last Modified:	19 Jan 2023 07:24
DOI:	10.18632/aging.101112
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3004764