<SUP>68</SUP>Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management

Lamarca, Angela, Pritchard, D Mark ORCID: 0000-0001-7971-3561, Westwood, Thomas, Papaxoinis, Georgios, Nonaka, Daisuke, Vinjamuri, Sobhan, Valle, Juan W, Manoharan, Prakash and Mansoor, Wasat (2018) <SUP>68</SUP>Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management. NEUROENDOCRINOLOGY, 106 (2). pp. 128-138.

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Abstract

<h4>Background</h4>68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear.<h4>Methods</h4>All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified retrospectively. The primary objective was to assess the impact of 68Ga-DOTANOC-PET on clinical management in patients with LC.<h4>Results</h4>Of 166 patients screened, 46 were eligible: 52% female, median age 57 years (range 21-86); type of LC: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (4%), typical (44%), atypical (35%), not reported (17%); stage: localised (63%), locally advanced (13%), and metastatic (17%) (7% unknown). A total of 47 68Ga-DOTANOCs were performed with the following rationale: LC diagnosis confirmation (4; 9%), primary tumour identification (2; 4%), post-surgical assessment (19; 40%), staging (patients with known LC present at time of 68Ga-DOTANOC) (19; 40%), and consideration of peptide receptor radionuclide therapy (3; 7%). Twenty-seven (57%) scans showed evidence of non-physiological uptake: median maximum standardised uptake value 7.2 (range 1.42-53). 68Ga-DOTANOC provided additional information in 37% (95% CI 22-51) of patients and impacted on management in 26% (95% CI 12-41); 9 patients (21%) were identified to have occult sites of metastases. Out of the 19 patients with post-surgical 68Ga-DOTANOC, 3 (16%) were identified to have distant metastases. There were no differences in the rate of practice changing 68Ga-DOTANOC results by type of LC (p value 0.5).<h4>Conclusions</h4>Our results support the role of 68Ga-DOTANOC for optimising the management of patients with LC, including post-surgical re-staging due to the potential for identifying occult metastases.

Item Type:	Article
Uncontrolled Keywords:	Gallium, DOTANOC, Positron emission tomography, Lung carcinoid, Lung, Neuroendocrine tumour
Depositing User:	Symplectic Admin
Date Deposited:	05 May 2017 11:15
Last Modified:	13 Oct 2023 18:11
DOI:	10.1159/000472717
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3007265