Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits



Evangelou, Evangelos, Warren, Helen R, Mosen-Ansorena, David, Mifsu, Borbala, Pazoki, Raha, Gao, He, Ntritsos, Georgios, Dimou, Niki, Cabrer, Claudia P, Karaman, Ibrahim
et al (show 271 more authors) (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50. 1412 - 1425.

[img] Text
49852_3_merged_1530094383.pdf - Accepted Version

Download (2MB)
[img] Text
BP_NG_A47255R2_Integrated_Supplementary_Figure_template_210618.docx - Accepted Version

Download (7MB)
[img] Text
BP_NG_A47255R2_SuppInfo_210618.docx - Accepted Version

Download (355kB)
[img] Spreadsheet
BP_NG_A47255R2_SupTablesMega_FinalEdits_210618.xlsx - Accepted Version

Download (5MB)

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Item Type: Article
Uncontrolled Keywords: Cardiovascular diseases, Genome informatics, Genome-wide association studies
Depositing User: Symplectic Admin
Date Deposited: 08 Oct 2018 09:26
Last Modified: 27 Nov 2020 08:10
DOI: 10.1038/s41588-018-0205-x
Related URLs:
URI: http://livrepository.liverpool.ac.uk/id/eprint/3027180