Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach



Chan, Christina YS, Roberts, Owain, Rajoli, Rajith KR ORCID: 0000-0002-6015-5712, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Siccardi, Marco ORCID: 0000-0002-3539-7867, Almond, Lisa and Owen, Andrew ORCID: 0000-0002-9819-7651
(2018) Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach. DRUG METABOLISM AND PHARMACOKINETICS, 33 (4). 179 - 187.

[img] Text
DMPK-Kdeg-Manuscript_Accepted-changes.docx - Accepted Version

Download (2MB)
Item Type: Article
Uncontrolled Keywords: Cytochrome P450, Drug-drug interactions, Degradation rate constant, Human hepatocytes, Mechanism-based inhibition, Physiologically-based pharmacokinetic modelling, Small-interfering RNA, Half-life, Time-dependent inhibition
Depositing User: Symplectic Admin
Date Deposited: 02 Nov 2018 09:06
Last Modified: 21 Apr 2021 17:03
DOI: 10.1016/j.dmpk.2018.01.004
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3028280