Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disorders



Suo, Xueling, Lei, Du, Li, Lei, Li, Wenbin, Dai, Jing, Wang, Song, He, Manxi, Zhu, Hongyan, Kemp, Graham J ORCID: 0000-0002-8324-9666 and Gong, Qiyong
(2018) Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disorders. Journal of psychiatry & neuroscience : JPN, 43 (6). 427 - ?.

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Abstract

<h4>Background</h4>Brain connectome research based on graph theoretical analysis shows that small-world topological properties play an important role in the structural and functional alterations observed in patients with psychiatric disorders. However, the reported global topological alterations in small-world properties are controversial, are not consistently conceptualized according to agreed-upon criteria, and are not critically examined for consistent alterations in patients with each major psychiatric disorder.<h4>Methods</h4>Based on a comprehensive PubMed search, we systematically reviewed studies using noninvasive neuroimaging data and graph theoretical approaches for 6 major psychiatric disorders: schizophrenia, major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), obsessive–compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Here, we describe the main patterns of altered small-world properties and then systematically review the evidence for these alterations in the structural and functional connectome in patients with these disorders.<h4>Results</h4>We selected 40 studies of schizophrenia, 33 studies of MDD, 5 studies of ADHD, 5 studies of BD, 7 studies of OCD and 5 studies of PTSD. The following 4 patterns of altered small-world properties are defined from theperspectives of segregation and integration: "regularization," "randomization," "stronger small-worldization" and "weaker small-worldization." Although more differences than similarities are noted in patients with these disorders, a prominent trend is the structural regularization versus functional randomization in patients with schizophrenia.<h4>Limitations</h4>Differences in demographic and clinical characteristics, preprocessing steps and analytical methods can produce contradictory results, increasing the difficulty of integrating results across different studies.<h4>Conclusion</h4>Four psychoradiological patterns of altered small-world properties are proposed. The analysis of altered smallworld properties may provide novel insights into the pathophysiological mechanisms underlying psychiatric disorders from a connectomic perspective. In future connectome studies, the global network measures of both segregation and integration should be calculated to fully evaluate altered small-world properties in patients with a particular disease.

Item Type: Article
Uncontrolled Keywords: Neural Pathways, Humans, Mental Disorders, Neuroimaging, Connectome
Depositing User: Symplectic Admin
Date Deposited: 25 Jan 2019 14:14
Last Modified: 14 Jun 2022 20:11
DOI: 10.1503/jpn.170214
URI: https://livrepository.liverpool.ac.uk/id/eprint/3030753