Burgoyne, Robert D ORCID: 0000-0002-9219-0387, Helassa, Nordine ORCID: 0000-0003-3743-1886, McCue, Hannah V and Haynes, Lee P ORCID: 0000-0002-1296-0338
(2019)
Calcium Sensors in Neuronal Function and Dysfunction.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 11 (5).
a035154-.
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Revised Burgoyne Chpt16.pdf - Author Accepted Manuscript Download (2MB) |
Abstract
Calcium signaling in neurons as in other cell types can lead to varied changes in cellular function. Neuronal Ca<sup>2+</sup> signaling processes have also become adapted to modulate the function of specific pathways over a wide variety of time domains and these can have effects on, for example, axon outgrowth, neuronal survival, and changes in synaptic strength. Ca<sup>2+</sup> also plays a key role in synapses as the trigger for fast neurotransmitter release. Given its physiological importance, abnormalities in neuronal Ca<sup>2+</sup> signaling potentially underlie many different neurological and neurodegenerative diseases. The mechanisms by which changes in intracellular Ca<sup>2+</sup> concentration in neurons can bring about diverse responses is underpinned by the roles of ubiquitous or specialized neuronal Ca<sup>2+</sup> sensors. It has been established that synaptotagmins have key functions in neurotransmitter release, and, in addition to calmodulin, other families of EF-hand-containing neuronal Ca<sup>2+</sup> sensors, including the neuronal calcium sensor (NCS) and the calcium-binding protein (CaBP) families, play important physiological roles in neuronal Ca<sup>2+</sup> signaling. It has become increasingly apparent that these various Ca<sup>2+</sup> sensors may also be crucial for aspects of neuronal dysfunction and disease either indirectly or directly as a direct consequence of genetic variation or mutations. An understanding of the molecular basis for the regulation of the targets of the Ca<sup>2+</sup> sensors and the physiological roles of each protein in identified neurons may contribute to future approaches to the development of treatments for a variety of human neuronal disorders.
Item Type: | Article |
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Uncontrolled Keywords: | Neurons, Animals, Humans, Neurodegenerative Diseases, Receptors, Calcium-Sensing, Calcium Signaling, Protein Conformation |
Depositing User: | Symplectic Admin |
Date Deposited: | 11 Mar 2019 08:55 |
Last Modified: | 31 Jan 2024 18:35 |
DOI: | 10.1101/cshperspect.a035154 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3033887 |