Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a



Gordon, MA ORCID: 0000-0002-0629-0884
(2019) Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. Science Advances, 5 (2).

This is the latest version of this item.

[img] Text
Science Advances final.pdf - OA Published Version
Available under License : See the attached licence file.

Download (4MB)

Abstract

Epidemiological and immunological evidence suggests that some vaccines can reduce all-cause mortality through nonspecific changes made to innate immune cells. Here, we present the first data to describe the nonspecific immunological impact of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. We vaccinated healthy adults with Ty21a and assessed aspects of innate and adaptive immunity over the course of 6 months. Changes to monocyte phenotype/function were observed for at least 3 months. Changes to innate and adaptive immune cell cytokine production in response to stimulation with vaccine and unrelated nonvaccine antigens were observed over the 6-month study period. The changes that we have observed could influence susceptibility to infection through altered immune responses mounted to subsequently encountered pathogens. These changes could influence all-cause mortality.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 06 May 2020 10:02
Last Modified: 27 Oct 2021 11:26
DOI: 10.1126/sciadv.aau6849
Open Access URL: https://doi.org/10.1126/sciadv.aau6849
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3085434

Available Versions of this Item