Thinning rate over 24 months in ultrathin DSAEK

Fenech, Matthew T, Coco, Giulia, Pagano, Luca, Gadhvi, Kunal A, Titley, Mitchell, Levis, Hannah J ORCID: 0000-0002-3923-1178, Parekh, Mohit, Kaye, Stephen B ORCID: 0000-0003-0390-0592 and Romano, Vito ORCID: 0000-0002-5148-7643
(2023) Thinning rate over 24 months in ultrathin DSAEK. EYE, 37 (4). pp. 655-659.

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<h4>Aim</h4>To describe the changes in corneal graft thickness following ultrathin Descemet's Stripping Automated Endothelial Keratoplasty (UT-DSAEK) comparing pre- and postoperative values over a 24-month period.<h4>Methods</h4>In this retrospective single-center case series, patients who received eye bank-prepared tissues for UT-DSAEK surgery were included. Preoperative and postoperative graft thickness measurements were determined in the eye bank and in clinic using anterior segment optical coherence tomography (AS-OCT) images. Graft thickness measurements and their percentage change between preoperative values and values at 1 day, 1 week and 1, 6, 12, 24 months were calculated.<h4>Results</h4>In total, 47 eyes of 47 patients with a mean age of 69 ± 11 years (29 males) were included. Twnty-three patients had Fuchs' endothelial dystrophy (49%) and the remaining 24 had pseudophakic bullous keratopathy (51%). In total, 29/47 eyes underwent UT-DSAEK alone (62%) and 18/47 received combined cataract surgery as a triple procedure (38%). Preoperative donor graft thickness was 92 ± 28 μm. Compared to preoperative values, where graft thickness increased to 194 ± 101.3 μm at 1 day, 151.1 ± 71.4 μm at 1 week, and 108.4 ± 52.5 μm at 1 month. Graft thickness continued to gradually decrease over time until 6 months (91.7 ± 33.6 μm), and then plateaued at 12 months (83.9 ± 25.0 μm), showing minimal changes at 2 years (101.4 ± 37.5 μm).<h4>Conclusion</h4>Preoperative DSAEK graft thickness measurements as reported by the eye bank are a valid approximation of DSAEK graft thickness at 6 months after surgery and these measurements tend to stabilize over time up to 2 years after surgery.

Item Type: Article
Uncontrolled Keywords: Eye, Endothelium, Corneal, Humans, Fuchs' Endothelial Dystrophy, Tomography, Optical Coherence, Retrospective Studies, Aged, Aged, 80 and over, Middle Aged, Male, Descemet Stripping Endothelial Keratoplasty
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Clinical Directorate
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 15 Jun 2022 14:34
Last Modified: 31 May 2023 08:37
DOI: 10.1038/s41433-022-02011-8
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