Integrative neuromechanics of crawling in D. Melanogaster Larvae

Pehlevan, C, Paoletti, P ORCID: 0000-0001-6131-0377 and Mahadevan, L (2016) Integrative neuromechanics of crawling in D. Melanogaster Larvae. eLife, 5 (2016JU). e11031-.

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Official URL: https://elifesciences.org/articles/11031

Abstract

© Pehlevan et al.Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory feedback in a heterogeneous environment. Our results explain the basic observed phenomenology of crawling with and without proprioception, and elucidate the stabilizing role that proprioception plays in producing a robust crawling phenotype in the presence of biological perturbations. More generally, our approach allows us to make testable predictions on the effect of changing body-environment interactions on crawling, and serves as a step in the development of hierarchical models linking cellular processes to behavior.

Item Type:	Article
Uncontrolled Keywords:	Neurosciences, Bioengineering, 1 Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance
Depositing User:	Symplectic Admin
Date Deposited:	25 Jul 2016 15:25
Last Modified:	15 Mar 2024 06:50
DOI:	10.7554/eLife.11031
Open Access URL:	https://elifesciences.org/content/5/e11031
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3002520