Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment

Hofmann, Sigrun R, Kapplusch, Franz, Girschick, Hermann J, Morbach, Henner, Pablik, Jessica, Ferguson, Polly J and Hedrich, Christian M ORCID: 0000-0002-1295-6179 (2017) Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment. CURRENT OSTEOPOROSIS REPORTS, 15 (6). pp. 542-554.

Text
s11914-017-0405-9.pdf - Published version
Download (1MB)

Official URL: http://dx.doi.org/10.1007/s11914-017-0405-9

Abstract

<h4>Purpose of review</h4>Chronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder. We summarize the clinical presentation, diagnostic approaches, most recent advances in understanding the pathophysiology, and available treatment options and outcomes in CNO/CRMO.<h4>Recent findings</h4>Though the exact molecular pathophysiology of CNO/CRMO remains somewhat elusive, it appears likely that variable defects in the TLR4/MAPK/inflammasome signaling cascade result in an imbalance between pro- and anti-inflammatory cytokine expressions in monocytes from CNO/CRMO patients. In this context, we present previously unpublished data on cytokine and chemokine expression in monocytes and tissues. CNO/CRMO is an autoinflammatory bone disorder resulting from imbalanced cytokine expression from innate immune cells. Though the exact molecular pathophysiology remains unclear, variable molecular defects appear to result in inflammasome activation and pro-inflammatory cytokine expression in monocytes from CNO/CRMO patients. Recent advances suggest signaling pathways and single molecules as biomarkers for CNO/CRMO as well as future treatment targets.

Item Type:	Article
Uncontrolled Keywords:	Chronic non-bacterial osteomyelitis, CNO, Chronic recurrent multifocal osteomyelitis, CRMO, Treatment, Inflammation, Cytokine, Bone, Biomarkers
Depositing User:	Symplectic Admin
Date Deposited:	13 Nov 2017 07:46
Last Modified:	19 Jan 2023 06:50
DOI:	10.1007/s11914-017-0405-9
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3011945