Tacutu, Robi, Thornton, Daniel, Johnson, Emily, Budovsky, Arie, Barardo, Diogo, Craig, Thomas ORCID: 0000-0001-7029-310X, Diana, Eugene, Lehmann, Gilad, Toren, Dmitri, Wang, Jingwei et al (show 2 more authors)
(2017)
Human Ageing Genomic Resources: new and updated databases.
NUCLEIC ACIDS RESEARCH, 46 (D1).
D1083-D1090.
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Abstract
In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR’s main functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring >4000 species; (iii) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with >500 entries; (v) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGR is freely available online (http://genomics.senescence.info/).
Item Type: | Article |
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Uncontrolled Keywords: | Animals, Humans, Disease, Genomics, Aging, Longevity, Databases, Genetic, Genetic Variation, Cellular Senescence |
Depositing User: | Symplectic Admin |
Date Deposited: | 17 Nov 2017 16:33 |
Last Modified: | 19 Jan 2023 06:50 |
DOI: | 10.1093/nar/gkx1042 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3012389 |