Lucas, Claire M ORCID: 0000-0001-6674-7535, Scott, Laura J, Carmell, Natasha, Holcroft, Alison K, Hills, Robert K, Burnett, Alan K and Clark, Richard E ORCID: 0000-0002-1261-3299
(2018)
CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML.
Blood Advances, 2 (9).
pp. 964-968.
Text
964.full.pdf - Published version Download (812kB) |
Abstract
PP2A inhibition occurs in AML by 2 different pathways: CIP2A in normal karyotype patients and SETBP1 in adverse karyotype patients. AKTS473 phosphorylation is a predictor of survival, and diagnostic levels of AKTS473 could be a novel biomarker in AML.
Item Type: | Article |
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Uncontrolled Keywords: | Humans, Intracellular Signaling Peptides and Proteins, Carrier Proteins, Membrane Proteins, Nuclear Proteins, Autoantigens, Phosphorylation, Adult, Middle Aged, Female, Male, Proto-Oncogene Proteins c-akt, Leukemia, Myeloid, Acute, Protein Phosphatase 2, Biomarkers, Tumor |
Depositing User: | Symplectic Admin |
Date Deposited: | 19 Jul 2018 10:20 |
Last Modified: | 19 Jan 2023 01:30 |
DOI: | 10.1182/bloodadvances.2017013615 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3023905 |