Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders

Sutton, R ORCID: 0000-0001-6600-562X (2018) Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders. Journal of Cellular and Molecular Medicine, 22 (10). pp. 4617-4629.

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Abstract

Histones are positively charged nuclear proteins that facilitate packaging of DNA into nucleosomes common to all eukaryotic cells. Upon cell injury or cell signalling processes, histones are released passively through cell necrosis or actively from immune cells as part of extracellular traps. Extracellular histones function as microbicidal proteins and are pro-thrombotic, limiting spread of infection or isolating areas of injury to allow for immune cell infiltration, clearance of infection and initiation of tissue regeneration and repair. Histone toxicity, however, is not specific to microbes and contributes to tissue and end-organ injury, which in cases of systemic inflammation may lead to organ failure and death. This review details the processes of histones release in acute inflammation, the mechanisms of histone-related tissue toxicity and current and future strategies for therapy targeting histones in acute inflammatory diseases.

Item Type:	Article
Uncontrolled Keywords:	extracellular histones, immunothrombosis, inflammation, innate immunity
Depositing User:	Symplectic Admin
Date Deposited:	08 Aug 2018 13:30
Last Modified:	19 Jan 2023 01:29
DOI:	10.1111/jcmm.13797
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3024756