Hypoxia and Chromatin, a Focus on Transcriptional Repression Mechanisms

Batie, Michael, del Peso, Luis and Rocha, Sonia ORCID: 0000-0002-2413-4981 (2018) Hypoxia and Chromatin, a Focus on Transcriptional Repression Mechanisms. Biomedicines.

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Official URL: http://dx.doi.org/10.20944/preprints201803.0004.v1

Abstract

Hypoxia, or reduced oxygen availability, has been studied extensively for its ability to activate specific genes. Hypoxia induced gene expression is mediated by the HIF transcription factors, although not exclusively so. Despite the great knowledge on the mechanisms by which hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms, but also the potential roles of dioxygenases with functions at the nucleosome and DNA level. Finally, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.

Item Type:	Article
Uncontrolled Keywords:	Genetics, 2 Aetiology, 2.1 Biological and endogenous factors, 1 Underpinning research, 1.1 Normal biological development and functioning
Depositing User:	Symplectic Admin
Date Deposited:	17 May 2019 07:29
Last Modified:	15 Mar 2024 14:04
DOI:	10.20944/preprints201803.0004.v1
Open Access URL:	https://www.mdpi.com/2227-9059/6/2/47
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3041454