Could ZI have a role in DBS for Parkinson's Disease? An observational study to optimize DBS target localization

De Marco, Raffaele, Bhargava, Deepti, Macerollo, Antonella ORCID: 0000-0003-4322-2706 and Osman-Farah, Jibril (2020) Could ZI have a role in DBS for Parkinson's Disease? An observational study to optimize DBS target localization. JOURNAL OF CLINICAL NEUROSCIENCE, 77. pp. 89-93.

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Abstract

Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is a well-recognized intervention for Parkinson's Disease (PD). We used LEAD-DBS, a toolbox facilitating DBS electrode reconstructions and computer simulations based on postoperative MRI and CT imaging, to investigate the interaction and followed benefits of electrical field generated by STN-DBS and surrounding areas, such as caudal Zona Incerta (cZI). Thirty-two PD patients, treated with directional STN-DBS in the period 2016-2018 at the Walton Center NHS Foundation Trust, were retrospectively recruited. Their MRI and CT imaging were analyzed with LEAD-DBS to measure the volume of tissue activated (VTA). Considering the clinical outcome based on the UPDRS III score improvement of 62.65% at 6 months follow up, we found a VTA intersection of 21.5% with motor STN and 61.7% with cZI. These observations may support the contribution of cZI deep stimulation to improve clinical outcome of PD patients treated with DBS, promoting the intriguing path of dual targeting.

Item Type:	Article
Uncontrolled Keywords:	Parkinson's Disease, DBS, STN, ZI, VTA, Directional stimulation
Depositing User:	Symplectic Admin
Date Deposited:	26 May 2020 08:19
Last Modified:	18 Jan 2023 23:51
DOI:	10.1016/j.jocn.2020.05.029
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3088722