Riasat, Kiran ORCID: 0000-0002-2512-8612, Bardell, David ORCID: 0000-0003-1573-1706, Goljanek-Whysall, Kasia ORCID: 0000-0001-8166-8800, Clegg, Peter and Peffers, Mandy ORCID: 0000-0001-6979-0440
(2020)
Epigenetic mechanisms in tendon ageing.
British Medical Bulletin, 135 (1).
pp. 90-107.
This is the latest version of this item.
Text
BMB-2020-016.R1_Proof_hi.pdf - Author Accepted Manuscript Download (916kB) | Preview |
|
Text
ldaa023.pdf - Published version Download (539kB) | Preview |
Abstract
Introduction Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes. This review summarizes epigenetic mechanisms identified in ageing healthy tendon. Sources of data We searched multiple databases to produce a systematic review on the role of epigenetic mechanisms in tendon ageing. Areas of agreement Epigenetic mechanisms are important in predisposing ageing tendon to injury. Areas of controversy The relative importance of epigenetic mechanisms are unknown in terms of promoting healthy ageing. It is also unknown whether these changes represent protective mechanisms to function or predispose to pathology. Growing point Epigenetic markers in ageing tendon, which are under-researched including genome-wide chromatin accessibility, should be investigated. Areas timely for developing research Metanalysis through integration of multiple datasets and platforms will enable a holistic understanding of the epigenome in ageing and its relevance to disease.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | tendon, ageing, epigenetics, histone modification, non-coding RNAs, DNA methylation |
Depositing User: | Symplectic Admin |
Date Deposited: | 26 Aug 2020 08:47 |
Last Modified: | 18 Jan 2023 23:36 |
DOI: | 10.1093/bmb/ldaa023 |
Open Access URL: | http://doi.org/10.1093/bmb/ldaa023 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3098907 |
Available Versions of this Item
-
Epigenetic mechanisms in tendon ageing. (deposited 21 Jul 2020 07:50)
- Epigenetic mechanisms in tendon ageing. (deposited 26 Aug 2020 08:47) [Currently Displayed]