Designing single trigger/dual-response release and degradation into amine-functional hyperbranched-polydendron nanoprecipitates

Rogers, Hannah E, Chambon, Pierre, Flynn, Sean ORCID: 0000-0001-6028-3389, Hern, Faye Y, Owen, Andrew ORCID: 0000-0002-9819-7651 and Rannard, Steve P ORCID: 0000-0002-6946-1097 (2020) Designing single trigger/dual-response release and degradation into amine-functional hyperbranched-polydendron nanoprecipitates. NANOSCALE ADVANCES, 2 (11). pp. 5468-5477.

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Official URL: http://dx.doi.org/10.1039/d0na00696c

Abstract

The synthesis of complex polymer architectures using relatively facile experimental protocols provides access to materials with the opportunity to control functionality and physical behaviour. The scope of hyperbranched-polydendron chemistries has been expanded here to include primary chains comprising amine-functional 'homopolymer', 'statistical copolymer' and amphiphilic 'block copolymer' analogues using 2-(diethyl amino)ethyl methacrylate, 2-hydroxy propyl methacrylate and <i>t</i>-butyl methacrylate. The different primary chain chemistry and architectures leads to a marked variation in nanoprecipitation behaviour and the response of the resulting amine-functional nanoparticles to varying pH. When acid-sensitive and acid-stable branchers, 1,4-butanediol di(methacryoyloxy)-ethyl ether and ethylene glycol dimethacrylate respectively, are utilised, nanoparticles with encapsulation properties are formed and may be triggered to either release-and-disassemble or release-disassemble-degrade to form a solution of lower molecular weight constituent primary chains.

Item Type:	Article
Depositing User:	Symplectic Admin
Date Deposited:	04 Dec 2020 10:59
Last Modified:	18 Jan 2023 23:19
DOI:	10.1039/d0na00696c
Open Access URL:	https://pubs.rsc.org/en/content/articlehtml/2020/N...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3109182