Dearomatizing Amination Reactions

Jing, Changcheng, Farndon, Joshua J and Bower, John F ORCID: 0000-0002-7551-8221 (2021) Dearomatizing Amination Reactions. CHEMICAL RECORD, 21 (10). pp. 2909-2926.

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Official URL: http://dx.doi.org/10.1002/tcr.202100104

Abstract

Dearomatization reactions allow the direct synthesis of structurally complex sp<sup>3</sup> -rich molecules from readily available "flat" precursors. Established dearomatization processes commonly involve the formation of new C-C bonds, whereas methods that enable the introduction of C-N bonds have received less attention. Because of the privileged position of nitrogen in drug discovery, significant recent methodological efforts have been directed towards addressing this deficiency. Consequently, a variety of new processes are now available that allow the direct preparation of sp<sup>3</sup> -rich amino-containing building blocks and scaffolds. This review gives an overview of C-N bond forming dearomatization reactions, particularly with respect to scaffold assembly processes. The discussion gives historical context, but the main focus is on selected methods that have been reported recently.

Item Type:	Article
Uncontrolled Keywords:	amination, dearomatization, spirocycle, heterocycle, electrophilic nitrogen
Divisions:	Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	14 Jun 2021 14:06
Last Modified:	18 Jan 2023 22:34
DOI:	10.1002/tcr.202100104
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3126332