McEvoy, L 
ORCID: 0000-0002-2169-6735, Carr, DF and Pirmohamed, M ORCID: 0000-0002-7534-7266
(2021)
Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity.
FRONTIERS IN PHARMACOLOGY, 12.
684162-.
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary prevention of cardiovascular disease. Chronic non-steroidal anti-inflammatory drug use is associated with potentially serious upper gastrointestinal adverse drug reactions (ADRs) including peptic ulcer disease and gastrointestinal bleeding. A few clinical and genetic predisposing factors have been identified; however, genetic data are contradictory. Further research is needed to identify clinically relevant genetic and non-genetic markers predisposing to NSAID-induced peptic ulceration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | pharmacogenomic, NSAID (non-steroidal anti-inflammatory drug), gastrointestinal toxicities, aspirin, adverse drug reaction |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Jul 2021 13:37 |
| Last Modified: | 18 Jan 2023 21:37 |
| DOI: | 10.3389/fphar.2021.684162 |
| Open Access URL: | https://doi.org/10.3389/fphar.2021.684162 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3128425 |
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