Sivasudhan, Enakshi, Blake, Neil, Lu, Zhi-Liang, Meng, Jia 
ORCID: 0000-0003-3455-205X and Rong, Rong
(2021)
Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9.
642443-.
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Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma.pdf - Published version Download (1MB) | Preview |
Abstract
Epidemiological data consistently rank hepatocellular carcinoma (HCC) as one of the leading causes of cancer-related deaths worldwide, often posing severe economic burden on health care. While the molecular etiopathogenesis associated with genetic and epigenetic modifications has been extensively explored, the biological influence of the emerging field of epitranscriptomics and its associated aberrant RNA modifications on tumorigenesis is a largely unexplored territory with immense potential for discovering new therapeutic approaches. In particular, the underlying cellular mechanisms of different hallmarks of hepatocarcinogenesis that are governed by the complex dynamics of m6A RNA methylation demand further investigation. In this review, we reveal the up-to-date knowledge on the mechanistic and functional link between m6A RNA methylation and pathogenesis of HCC.
| Item Type: | Article |
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| Uncontrolled Keywords: | hepatocellular carcinoma, epitranscriptomics, m6A RNA methylation, cancer hallmarks, writers, erasers, readers |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Science and Engineering > School of Electrical Engineering, Electronics and Computer Science |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 12 Jul 2021 07:12 |
| Last Modified: | 18 Jan 2023 21:36 |
| DOI: | 10.3389/fcell.2021.642443 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3129691 |
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