Staton, Gareth J 
ORCID: 0000-0003-4100-8597, Angell, Joseph W, Grove-White, Dai ORCID: 0000-0002-5969-5535, Clegg, Simon R, Carter, Stuart D ORCID: 0000-0002-3585-9400, Evans, Nicholas J ORCID: 0000-0002-2950-1007 and Duncan, Jennifer S ORCID: 0000-0002-1370-3085
(2021)
Contagious Ovine Digital Dermatitis: A Novel Bacterial Etiology and Lesion Pathogenesis.
FRONTIERS IN VETERINARY SCIENCE, 8.
722461-.
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Contagious Ovine Digital Dermatitis A Novel Bacterial Etiology and Lesion Pathogenesis.pdf - Author Accepted Manuscript Download (3MB) | Preview |
Abstract
Contagious ovine digital dermatitis (CODD) is a severe and common infectious foot disease of sheep and a significant animal welfare issue for the sheep industry in the UK and some European countries. The etiology and pathogenesis of the disease are incompletely understood. In this longitudinal, experimental study, CODD was induced in 18 sheep, and for the first time, the clinical lesion development and associated microbiological changes in CODD affected feet are described over time, resulting in a completely new understanding of the etiopathogenesis of CODD. The majority of CODD lesions (83.9%) arose from pre-existing interdigital dermatitis (ID) and/or footrot (FR) lesions. All stages of foot disease were associated with high levels of poly-bacterial colonization with five pathogens, which were detected by quantitative PCR (qPCR): <i>Treponema medium, Treponema phagedenis, Treponema pedis, Dichelobacter nodosus</i>, and <i>Fusobacterium necrophorum</i>. Temporal colonization patterns showed a trend for early colonization by <i>T. phagedenis</i>, followed by <i>F. necrophorum</i> and <i>D. nodosus, T. medium</i>, and then <i>T. pedis, D. nodosus</i> was present at significantly higher predicted mean log<sub>10</sub> genome copy numbers in FR lesions compared to both ID and CODD, while <i>Treponema</i> species were significantly higher in CODD and FR lesions compared to ID lesions (<i>p</i> < 0.001). Treatment of CODD-affected sheep with two doses of 10 mg/kg long acting amoxicillin resulted in a 91.7% clinical cure rate by 3 weeks post-treatment; however, a bacteriological cure was not established for all CODD-affected feet. The study found that in an infected flock, healthy feet, healed CODD feet, and treated CODD feet can be colonized by some or all of the five pathogens associated with CODD and therefore could be a source of continued infection in flocks. The study is an experimental study, and the findings require validation in field CODD cases. However, it does provide a new understanding of the etiopathogenesis of CODD and further supportive evidence for the importance of current advice on the control of CODD; namely, ensuring optimum flock control of footrot and prompt isolation and effective treatment of clinical cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sheep, lameness, CODD, footrot, Treponema medium, Treponema phagedenis, Treponema pedis, Dichelobacter nodosus |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Oct 2021 07:23 |
| Last Modified: | 18 Jan 2023 21:26 |
| DOI: | 10.3389/fvets.2021.722461 |
| Open Access URL: | https://www.frontiersin.org/article/10.3389/fvets.... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3141042 |
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