Sou, Ieng Fong, Pryce, Rebecca M, Tee, Wee-Wei and McClurg, Urszula Lucja ORCID: 0000-0003-2631-4174
(2021)
Meiosis initiation: a story of two sexes in all creatures great and small.
BIOCHEMICAL JOURNAL, 478 (20).
pp. 3791-3805.
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Abstract
Meiosis facilitates diversity across individuals and serves as a major driver of evolution. However, understanding how meiosis begins is complicated by fundamental differences that exist between sexes and species. Fundamental meiotic research is further hampered by a current lack of human meiotic cells lines. Consequently, much of what we know relies on data from model organisms. However, contextualising findings from yeast, worms, flies and mice can be challenging, due to marked differences in both nomenclature and the relative timing of meiosis. In this review, we set out to combine current knowledge of signalling and transcriptional pathways that control meiosis initiation across the sexes in a variety of organisms. Furthermore, we highlight the emerging links between meiosis initiation and oncogenesis, which might explain the frequent re-expression of normally silent meiotic genes in a variety of human cancers.
Item Type: | Article |
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Uncontrolled Keywords: | Animals, Xenopus laevis, Humans, Mice, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Neoplasms, Sex Factors, Signal Transduction, Meiosis, Oogenesis, Spermatogenesis, Gene Expression Regulation, Developmental, Time Factors, Female, Male, Carcinogenesis |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
Depositing User: | Symplectic Admin |
Date Deposited: | 02 Nov 2021 08:17 |
Last Modified: | 18 Jan 2023 21:25 |
DOI: | 10.1042/BCJ20210412 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3142370 |