The PINK1 repertoire: Not just a one trick pony

Pollock, Liam, Jardine, Jane, Urbe, Sylvie ORCID: 0000-0003-4735-9814 and Clague, Michael J ORCID: 0000-0003-3355-9479 (2021) The PINK1 repertoire: Not just a one trick pony. BIOESSAYS, 43 (11). e2100168-.

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Official URL: http://dx.doi.org/10.1002/bies.202100168

Abstract

PTEN-induced kinase 1 (PINK1) is a Parkinson's disease gene that acts as a sensor for mitochondrial damage. Its best understood role involves phosphorylating ubiquitin and the E3 ligase Parkin (PRKN) to trigger a ubiquitylation cascade that results in selective clearance of damaged mitochondria through mitophagy. Here we focus on other physiological roles of PINK1. Some of these also lie upstream of Parkin but others represent autonomous functions, for which alternative substrates have been identified. We argue that PINK1 orchestrates a multi-arm response to mitochondrial damage that impacts on mitochondrial architecture and biogenesis, calcium handling, transcription and translation. We further discuss a role for PINK1 in immune signalling co-ordinated at mitochondria and consider the significance of a freely diffusible cleavage product, that is constitutively generated and degraded under basal conditions.

Item Type:	Article
Uncontrolled Keywords:	ISR, mitochondria, mitochondrial quality control, mitophagy, Parkin, Parkinson's disease, PINK1, stress response
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	02 Nov 2021 13:38
Last Modified:	18 Jan 2023 21:25
DOI:	10.1002/bies.202100168
Open Access URL:	https://doi.org/10.1002/bies.202100168
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3142510