Sgreccia, Daria, Manicardi, Marcella, Malavasi, Vincenzo Livio, Vitolo, Marco 
ORCID: 0000-0002-5196-6249, Valenti, Anna Chiara, Proietti, Marco ORCID: 0000-0003-1452-2478, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Boriani, Giuseppe
(2021)
Comparing Outcomes in Asymptomatic and Symptomatic Atrial Fibrillation: A Systematic Review and Meta-Analysis of 81,462 Patients.
JOURNAL OF CLINICAL MEDICINE, 10 (17).
3979-.
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Comparing Outcomes in Asymptomatic and Symptomatic Atrial Fibrillation A Systematic Review and Meta-Analysis of 81,462 Patie.pdf - Published version Download (790kB) | Preview |
Abstract
<h4>Background</h4>In atrial fibrillation (AF) patients, the presence of symptoms can guide the decision between rate or rhythm control therapy, but it is still unclear if AF-related outcomes are determined by symptomatic status of their clinical presentation.<h4>Methods</h4>We performed a systematic review and metanalysis following the PRISMA recommendations on available studies that compared asymptomatic to symptomatic AF reporting data on all-cause mortality, cardiovascular death, and thromboembolic events (TEs). We included studies with a total number of patients enrolled equal to or greater than 200, with a minimum follow-up period of six months.<h4>Results</h4>From the initial 5476 results retrieved after duplicates' removal, a total of 10 studies were selected. Overall, 81,462 patients were included, of which 21,007 (26%) were asymptomatic, while 60,455 (74%) were symptomatic. No differences were found between symptomatic and asymptomatic patients regarding the risks of all-cause death (odds ratio (OR) 1.03, 95% confidence interval (CI) 0.81-1.32), and cardiovascular death (OR 0.87, 95% CI 0.54-1.39). No differences between symptomatic and asymptomatic groups were evident for stroke (OR 1.22, 95% CI 0.77-1.93) and stroke/TE (OR 1.06, 95% CI 0.86-1.31) risks.<h4>Conclusions</h4>Mortality and stroke/TE events in AF patients were unrelated to symptomatic status of their clinical presentation. Adoption of management strategies in AF patients should not be based on symptomatic clinical status.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | atrial fibrillation, symptoms, outcomes, stroke, mortality, meta-analysis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Dec 2021 15:56 |
| Last Modified: | 01 Feb 2024 02:18 |
| DOI: | 10.3390/jcm10173979 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3145300 |
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