Paterson, Ross W, Benjamin, Laura A 
ORCID: 0000-0002-9685-1664, Mehta, Puja R, Brown, Rachel L, Athauda, Dilan, Ashton, Nicholas J, Leckey, Claire A, Ziff, Oliver J, Heaney, Judith, Heslegrave, Amanda J et al (show 24 more authors)
(2021)
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes.
BRAIN COMMUNICATIONS, 3 (3).
fcab099-.
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Abstract
Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage occurs, we collected serum and CSF from patients with COVID-19 and characterized neurological syndromes involving the PNS and CNS (<i>n</i> = 34). We measured biomarkers of neuronal damage and neuroinflammation, and compared these with non-neurological control groups, which included patients with (<i>n</i> = 94) and without (<i>n</i> = 24) COVID-19. We detected increased concentrations of neurofilament light, a dynamic biomarker of neuronal damage, in the CSF of those with CNS inflammation (encephalitis and acute disseminated encephalomyelitis) [14 800 pg/ml (400, 32 400)], compared to those with encephalopathy [1410 pg/ml (756, 1446)], peripheral syndromes (Guillain-Barré syndrome) [740 pg/ml (507, 881)] and controls [872 pg/ml (654, 1200)]. Serum neurofilament light levels were elevated across patients hospitalized with COVID-19, irrespective of neurological manifestations. There was not the usual close correlation between CSF and serum neurofilament light, suggesting serum neurofilament light elevation in the non-neurological patients may reflect peripheral nerve damage in response to severe illness. We did not find significantly elevated levels of serum neurofilament light in community cases of COVID-19 arguing against significant neurological damage. Glial fibrillary acidic protein, a marker of astrocytic activation, was not elevated in the CSF or serum of any group, suggesting astrocytic activation is not a major mediator of neuronal damage in COVID-19.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19, NfL, encephalitis, ADEM |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Feb 2022 15:27 |
| Last Modified: | 18 Jan 2023 21:14 |
| DOI: | 10.1093/braincomms/fcab099 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3147964 |
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