Dual-responsive degradable core-shell nanogels with tuneable aggregation behaviour

Gray, Dominic M, Town, Adam R, Niezabitowska, Edyta, Rannard, Steve P ORCID: 0000-0002-6946-1097 and McDonald, Tom O ORCID: 0000-0002-9273-9173 (2022) Dual-responsive degradable core-shell nanogels with tuneable aggregation behaviour. RSC ADVANCES, 12 (4). pp. 2196-2206.

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Abstract

We report the synthesis of core-shell nanogels by sequential addition of thermoresponsive monomers; <i>N</i>-isopropylacrylamide (NIPAM) and <i>N</i>-isopropylmethacrylamide (NIPMAM). The aggregation behaviour of aqueous dispersions of these particles in the presence of salt can be tuned by varying the monomer ratio. The inclusion of degradable cross-linker bis(acryloyl)cystamine (BAC) allows the nanogels to degrade in the presence of reducing agent, with nanogels composed of a copolymer of the two monomers not showing the same high levels of degradation as the comparable core-shell particles. These levels of degradation were also seen with physiologically relevant reducing agent concentration at pH 7. Therefore, it is hoped that the aggregation of these nanogels will have applications in nanomedicine and beyond.

Item Type:	Article
Divisions:	Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Feb 2022 16:13
Last Modified:	18 Jan 2023 21:14
DOI:	10.1039/d1ra07093b
Open Access URL:	https://doi.org/10.1039/D1RA07093B
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3147971