New Developments in Gastric Neuroendocrine Neoplasms

Exarchou, Klaire, Stephens, Nathan A, Moore, Andrew R, Howes, Nathan R and Pritchard, D Mark ORCID: 0000-0001-7971-3561 (2022) New Developments in Gastric Neuroendocrine Neoplasms. Current Oncology Reports, 24 (1). pp. 77-88.

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Official URL: http://dx.doi.org/10.1007/s11912-021-01175-y

Abstract

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose of Review</jats:title> <jats:p>Gastric neuroendocrine neoplasms (g-NENs) are a rare type of stomach cancer. The three main subtypes have different pathogeneses, biological behaviours and clinical characteristics, so they require different management strategies. This article will provide an overview of g-NENs and highlight recent advances in the field.</jats:p> </jats:sec><jats:sec> <jats:title>Recent Findings</jats:title> <jats:p>Molecular profiling has revealed differences between indolent and aggressive g-NENs, as well as a new somatic mutation responsible for some familial type I g-NENs. Novel biomarkers have been developed which will hopefully improve diagnosis, treatment, risk stratification and follow-up. Patient treatment is also changing, as evidence supports the use of less aggressive options (e.g. endoscopic surveillance or resection) in some patients with more indolent tumours.</jats:p> </jats:sec><jats:sec> <jats:title>Summary</jats:title> <jats:p>g-NEN heterogeneity poses challenges in understanding and managing this rare disease. More basic science research is needed to investigate molecular pathogenesis, and future larger clinical studies will hopefully also further improve treatment and patient outcomes.</jats:p> </jats:sec>

Item Type:	Article
Uncontrolled Keywords:	Gastrin, Neuroendocrine tumour, Carcinoid, Enterochromaffin-like (ECL)-cell, stomach, Atrophic gastritis
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	07 Feb 2022 11:30
Last Modified:	18 Jan 2023 21:13
DOI:	10.1007/s11912-021-01175-y
Open Access URL:	https://link.springer.com/article/10.1007%2Fs11912...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3148398