Asiimwe, Innocent G 
ORCID: 0000-0002-1196-1822 and Pirmohamed, Munir ORCID: 0000-0002-7534-7266
(2022)
Ethnic Diversity and Warfarin Pharmacogenomics.
Frontiers in Pharmacology, 13.
866058-.
Abstract
<jats:p>Warfarin has remained the most commonly prescribed vitamin K oral anticoagulant worldwide since its approval in 1954. Dosing challenges including having a narrow therapeutic window and a wide interpatient variability in dosing requirements have contributed to making it the most studied drug in terms of genotype-phenotype relationships. However, most of these studies have been conducted in Whites or Asians which means the current pharmacogenomics evidence-base does not reflect ethnic diversity. Due to differences in minor allele frequencies of key genetic variants, studies conducted in Whites/Asians may not be applicable to underrepresented populations such as Blacks, Hispanics/Latinos, American Indians/Alaska Natives and Native Hawaiians/other Pacific Islanders. This may exacerbate health inequalities when Whites/Asians have better anticoagulation profiles due to the existence of validated pharmacogenomic dosing algorithms which fail to perform similarly in the underrepresented populations. To examine the extent to which individual races/ethnicities are represented in the existing body of pharmacogenomic evidence, we review evidence pertaining to published pharmacogenomic dosing algorithms, including clinical utility studies, cost-effectiveness studies and clinical implementation guidelines that have been published in the warfarin field.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ancestry, ethnic diversity, underrepresented populations, pharmacogenetics, pharmacogenomics |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Apr 2022 08:22 |
| Last Modified: | 18 Jan 2023 21:05 |
| DOI: | 10.3389/fphar.2022.866058 |
| Open Access URL: | https://www.frontiersin.org/articles/10.3389/fphar... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3152353 |
Dimensions
Dimensions
