Aggarwal, Dinesh, Warne, Ben, Jahun, Aminu S, Hamilton, William L, Fieldman, Thomas, du Plessis, Louis, Hill, Verity, Blane, Beth, Watkins, Emmeline, Wright, Elizabeth et al (show 33 more authors)
(2022)
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
NATURE COMMUNICATIONS, 13 (1).
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Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.pdf - Published version Download (2MB) | Preview |
Abstract
Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cambridge Covid-19 testing Centre, University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium, COVID-19 Genomics UK (COG-UK) Consortium, Humans, RNA, Viral, Contact Tracing, Risk Factors, Genomics, Phylogeny, Genome, Viral, Students, Universities, United Kingdom, COVID-19, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 19 Apr 2022 10:04 |
| Last Modified: | 18 Jan 2023 21:05 |
| DOI: | 10.1038/s41467-021-27942-w |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3153182 |
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