Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review.

Ajoolabady, Amir ORCID: 0000-0002-3667-2605, Nattel, Stanley, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Ren, Jun ORCID: 0000-0002-0275-0783 (2022) Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 79 (23). pp. 2349-2366.

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Abstract

As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in patients with cardiovascular diseases. Despite the multifaceted nature of AF pathogenesis and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3 inflammasome activation contributes to onset and progression of AF. Herein, the authors aim at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis, and novel therapeutic options in the management of AF.

Item Type:	Article
Uncontrolled Keywords:	Humans, Atrial Fibrillation, Thromboembolism, Heart Failure, Stroke, Inflammasomes
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	14 Jul 2022 07:38
Last Modified:	17 Mar 2024 14:30
DOI:	10.1016/j.jacc.2022.03.379
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3158460