Duckworth, Jay J 
ORCID: 0000-0002-9475-5839, Wright, Hazel, Christiansen, Paul, Rose, Abi ORCID: 0000-0003-3267-7318 and Fallon, Nicholas ORCID: 0000-0003-1451-6983
(2022)
Sign-tracking modulates reward-related neural activation to reward cues, but not reward feedback.
The European journal of neuroscience, 56 (7).
pp. 5000-5013.
Abstract
Research shows cognitive and neurobiological overlap between sign-tracking (value-modulated attentional capture [VMAC] by response-irrelevant, discrete cues) and maladaptive behaviour (e.g., substance abuse). We investigated the neural correlates of sign-tracking in 20 adults using an additional singleton task (AST) and functional Magnetic Resonance Imaging (fMRI). Participants responded to a target to win monetary reward, the amount of which was signalled by singleton type (reward cue: high-value vs. low-value). Singleton responses resulted in monetary deductions. Sign-tracking - greater distraction by high-value vs. low-value singletons (H>L) - was observed, with high-value singletons producing slower responses to the target than low-value singletons. Controlling for age and sex, analyses revealed no differential brain activity across H>L singletons. Including sign-tracking as a regressor of interest revealed increased activity (H>L singletons) in cortico-subcortical loops, regions associated with Pavlovian conditioning, reward processing, attention shifts, and relative value coding. Further analyses investigated responses to reward feedback (H>L). Controlling for age and sex, increased activity (H>L reward feedback) was found in regions associated with reward anticipation, attentional control, success monitoring, and emotion regulation. Including sign-tracking as a regressor of interest revealed increased activity in the temporal pole, a region related to value discrimination. Results suggest sign-tracking is associated with activation of the 'attention and salience network' in response to reward cues but not reward feedback, suggesting parcellation between the two at the level of the brain. Results add to the literature showing considerable overlap in neural systems implicated in reward processing, learning, habit formation, emotion regulation, and substance craving.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | fMRI, incentive salience, reward cues, selective attention, VMAC |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Aug 2022 09:08 |
| Last Modified: | 18 Jan 2023 20:47 |
| DOI: | 10.1111/ejn.15787 |
| Open Access URL: | https://doi.org/10.1111/ejn.15787 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3161955 |
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