Condensed Supramolecular Helices: The Twisted Sisters of DNA

Du, Guanqun ORCID: 0000-0003-0402-1071, Belić, Domagoj, Del Giudice, Alessandra ORCID: 0000-0002-1916-8300, Alfredsson, Viveka ORCID: 0000-0002-9733-2735, Carnerup, Anna M, Zhu, Kaizheng, Nyström, Bo, Wang, Yilin, Galantini, Luciano ORCID: 0000-0001-5484-2658 and Schillén, Karin ORCID: 0000-0001-8147-1733 (2022) Condensed Supramolecular Helices: The Twisted Sisters of DNA. Angewandte Chemie, 134 (4).

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Official URL: http://dx.doi.org/10.1002/ange.202113279

Abstract

<jats:title>Abstract</jats:title><jats:p>Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA‐like condensation with supramolecular helices of small chiral molecules, thereby demonstrating that it is a more general phenomenon. We show that the bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or block copolymers. At higher order, a controlled hexagonal packing of the helices into DNA‐like bundles and toroids could be accomplished. The results disclose unknown similarities between covalent and supramolecular non‐covalent helical polyelectrolytes, which inspire visionary ideas of constructing supramolecular versions of biological macromolecules. As drug nanocarriers the polymer–bile salt superstructures would get advantage of a complex chirality at molecular and supramolecular levels, whose effect on the nanocarrier assisted drug efficiency is a still unexplored fascinating issue.</jats:p>

Item Type:	Article
Divisions:	Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	13 Sep 2022 13:27
Last Modified:	05 Sep 2023 08:57
DOI:	10.1002/ange.202113279
Open Access URL:	https://doi.org/10.1002/ange.202113279
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3164536