Voronina, Svetlana, Chvanov, Michael, De Faveri, Francesca, Mayer, Ulrike, Wileman, Tom, Criddle, David ORCID: 0000-0003-2952-8450 and Tepikin, Alexei
(2022)
Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle.
CELLS, 11 (16).
2514-.
Text
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Abstract
Recent studies have highlighted the importance of autophagy and particularly non-canonical autophagy in the development and progression of acute pancreatitis (a frequent disease with considerable morbidity and significant mortality). An important early event in the development of acute pancreatitis is the intrapancreatic activation of trypsinogen, (i.e., formation of trypsin) leading to the autodigestion of the organ. Another prominent phenomenon associated with the initiation of this disease is vacuolisation and specifically the formation of giant endocytic vacuoles in pancreatic acinar cells. These organelles develop in acinar cells exposed to several inducers of acute pancreatitis (including taurolithocholic acid and high concentrations of secretagogues cholecystokinin and acetylcholine). Notably, early trypsinogen activation occurs in the endocytic vacuoles. These trypsinogen-activating organelles undergo activation, long-distance trafficking, and non-canonical autophagy. In this review, we will discuss the role of autophagy in acute pancreatitis and particularly focus on the recently discovered LAP-like non-canonical autophagy (LNCA) of endocytic vacuoles.
Item Type: | Article |
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Uncontrolled Keywords: | acute pancreatitis, ATG8, autophagy, CASM, cholecystokinin, endocytic vacuole, LAP, LAP-like non-canonical autophagy, LC3, LC3-associated phagocytosis, LNCA, non-canonical autophagy, pancreatic acinar cell, trypsin, trypsinogen, zymogen granule |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
Depositing User: | Symplectic Admin |
Date Deposited: | 14 Sep 2022 14:29 |
Last Modified: | 18 Jan 2023 20:41 |
DOI: | 10.3390/cells11162514 |
Open Access URL: | https://doi.org/10.3390/cells11162514 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3164696 |