Symbionts on the Brain: How <i>Wolbachia</i> Is Strictly Corralled in Some Neotropical <i>Drosophila</i> spp.


Voronin, Denis and Makepeace, Benjamin L ORCID: 0000-0002-6100-6727 (2022) Symbionts on the Brain: How <i>Wolbachia</i> Is Strictly Corralled in Some Neotropical <i>Drosophila</i> spp. MBIO, 13 (4). e0118222-.

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Abstract

<i>Wolbachia</i> is a heritable alphaproteobacterial symbiont of arthropods and nematodes, famous for its repertoire of host manipulations, including cytoplasmic incompatibility. To be vertically transmitted, <i>Wolbachia</i> must efficiently colonize the female germ line, although somatic tissues outside the gonads are also infected. In <i>Drosophila</i> spp., <i>Wolbachia</i> is usually distributed systemically in multiple regions of the adult fly, but in some neotropical hosts, <i>Wolbachia</i>'s only somatic niches are cerebral bacteriocyte-like structures and the ovarian follicle cells. In their recent article, Strunov and colleagues (A. Strunov, K. Schmidt, M. Kapun, and W. J. Miller. mBio 13:e03863-21, 2022, https://doi.org/10.1128/mbio.03863-21) compared the development of <i>Drosophila</i> spp. with systemic or restricted infections and demonstrated that the restricted pattern is determined in early embryogenesis by an apparently novel autophagic process, involving intimate interactions of <i>Wolbachia</i> with the endoplasmic reticulum. This work has implications not only for the evolution of neotropical <i>Drosophila</i> spp. but also for our understanding of how <i>Wolbachia</i> infections are controlled in other native or artificial hosts.

Item Type: Article
Uncontrolled Keywords: autophagy, endoplasmic reticulum, neuroblast, symbiosis
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 06 Oct 2022 13:48
Last Modified: 05 Oct 2023 11:41
DOI: 10.1128/mbio.01182-22
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3165211
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