Molloy, Sile F, Ross, Brad, Kanyama, Cecilia, Mfinanga, Sayoki, Lesikari, Sokoine, Heyderman, Robert S, Kalata, Newton, Ellis, Jayne, Kouanfack, Charles, Chanda, Duncan et al (show 15 more authors)
(2021)
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
OPEN FORUM INFECTIOUS DISEASES, 8 (4).
ofab066-.
Abstract
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH<sub>2</sub>O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36-4.83; <i>P</i> = .02) and fungal burden >6.0 log<sub>10</sub> colonies/mL (aOR, 3.01; 95% CI, 1.58-5.7; <i>P</i> = .003) were independently associated with severe visual loss.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cryptococcal meningitis, fungal burden, HIV, raised intracranial pressure, visual loss |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 12 Oct 2022 09:22 |
| Last Modified: | 18 Jan 2023 20:36 |
| DOI: | 10.1093/ofid/ofab066 |
| Open Access URL: | https://doi.org/10.1093/ofid/ofab066 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3165414 |
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