Wu, Di 
ORCID: 0000-0002-5622-7488, Jia, Yan, Cai, Wenhao ORCID: 0000-0002-4328-3341, Huang, Yilin, Kattakayam, Arjun, Latawiec, Diane, Sutton, Robert ORCID: 0000-0001-6600-562X and Peng, Jie
(2022)
Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients.
Front Cell Infect Microbiol, 12.
p. 1044188.
Abstract
INTRODUCTION: Multiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization. This study aims to evaluate the impact of MDR Gram-negative bacteraemia on IPN patients. METHODS: A case-control study was performed with data collected from 1 January 2016 to 1 July 2022 in a Chinese tertiary teaching hospital. Clinical data of the IPN patients with MDR-GNB bacteraemia were analyzed and compared to those of a matched control group without MDR-GNB bacteraemia (case-control ratio of 1:2). Comparisons were performed between with/without MDR-GNB bacteraemia and different severities of acute pancreatitis (AP). Independent predictors of overall mortality were identified via univariate and multivariate binary logistic regression analyses. RESULTS: MDR-GNB bacteraemia was related to a higher mortality rate (62.5% vs. 8.3%, p < 0.001). Severe AP combined with MDR-GNB bacteraemia further increased mortality up to 81.3% (p = 0.025). MDR-GNB bacteraemia (odds ratio (OR) = 8.976, 95% confidence interval (CI) = 1.805 -44.620, p = 0.007) and severe AP (OR = 9.414, 95% CI = 1.742 -50.873, p = 0.009) were independent predictors of overall mortality. MDR- Klebsiella pneumoniae was the most common causative pathogen. CONCLUSION: A higher mortality rate in IPN patients was related to MDR-GNB bacteraemia and further increased in severe AP patients combined with MDR-GNB bacteraemia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | acute pancreatitis, Gram-negative bacterial bacteraemia, infected pancreatic necrosis, mortality, multiple drug-resistant |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 15 Dec 2022 10:36 |
| Last Modified: | 28 Dec 2022 08:38 |
| DOI: | 10.3389/fcimb.2022.1044188 |
| Open Access URL: | https://www.frontiersin.org/articles/10.3389/fcimb... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3166688 |
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