Baguiya, Adama, Bonet, Mercedes, Cecatti, Jose Guilherme, Brizuela, Vanessa, Curteanu, Ala, Minkauskiene, Meile, Jayaratne, Kapila, Ribeiro-do-Valle, Carolina Carvalho, Budianu, Mihaela-Alexandra, Souza, Joao Paulo et al (show 1 more authors)
(2021)
Perinatal outcomes among births to women with infection during pregnancy.
ARCHIVES OF DISEASE IN CHILDHOOD, 106 (10).
pp. 946-953.
Abstract
<h4>Objective</h4>This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).<h4>Design</h4>We conducted a 1-week inception hospital-based cohort study.<h4>Setting</h4>The study was carried out in 408 hospitals in 43 LMIC of all the WHO regions in 2017.<h4>Patients</h4>We included women with suspected or confirmed infection during pregnancy with at least 28 weeks of gestational age up to day-7 after birth. All babies born to those women were followed from birth until the seventh day after childbirth. Perinatal outcomes were considered at the end of the follow-up.<h4>Main outcome measures</h4>Perinatal outcomes were (i) babies alive without severe complication, (ii) NNM and (iii) perinatal death (stillbirth and early neonatal death).<h4>Results</h4>1219 births were analysed. Among them, 25.9% (n=316) and 10.1% (n=123) were NNM and perinatal deaths, respectively. After adjustment, maternal pre-existing medical condition (adjusted odds ratios (aOR)=1.5; 95% CI 1.1 to 2.0) and maternal infection suspected or diagnosed during labour (aOR=1.9; 95% CI 1.2 to 3.2) were the independent risk factors of NNM. Maternal pre-existing medical condition (aOR=1.7; 95% CI 1.0 to 2.8), infection-related severe maternal outcome (aOR=3.8; 95% CI 2.0 to 7.1), mother's infection suspected or diagnosed within 24 hours after childbirth (aOR=2.2; 95% CI 1.0 to 4.7) and vaginal birth (aOR=1.8; 95% CI 1.1 to 2.9) were independently associated with increased odds of perinatal death.<h4>Conclusions</h4>Overall, one-third of births were adverse perinatal outcomes. Pre-existing maternal medical conditions and severe infection-related maternal outcomes were the main risk factors of adverse perinatal outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | epidemiology, neonatology |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 03 Feb 2023 10:29 |
| Last Modified: | 03 Feb 2023 10:29 |
| DOI: | 10.1136/archdischild-2021-321865 |
| Open Access URL: | https://adc.bmj.com/content/106/10/946 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3168139 |
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