Thu, May S, Ondee, Thunnicha, Nopsopon, Tanawin, Farzana, Izzati AK, Fothergill, Joanne L 
ORCID: 0000-0002-7012-1508, Hirankarn, Nattiya, Campbell, Barry J ORCID: 0000-0002-7407-012X and Pongpirul, Krit
(2023)
Effect of Probiotics in Breast Cancer: A Systematic Review and Meta-Analysis.
BIOLOGY-BASEL, 12 (2).
280-.
Abstract
Probiotics may have the potential to protect against breast cancer, partly through systemic immunomodulatory action and active impact upon intestinal microbiota. Given a few clinical studies on their curative role, we conducted a systematic review of the potential effects of probiotics in breast cancer patients and survivors of breast cancer, aiming to support further clinical studies. A literature search was performed using PubMed, Embase, and the CENTRAL databases from inception through to March 2022. A total of eight randomized clinical trials were identified from thirteen articles published between 2004 and 2022. We evaluated quality-of-life measures, observed bacterial species and diversity indices, probiotic-related metabolites, inflammatory biomarkers, and other responses in breast cancer patients and survivors. Results were synthesized qualitatively and quantitatively using random-effects meta-analysis. Different probiotics supplements utilized included <i>Lactobacillus</i> species alone (Lacto), with or without estriol; probiotic combinations of <i>Lactobacillus</i> with <i>Bifidobacterium</i> (ProLB), with or without prebiotic fructooligosaccharides (FOS); ProLB plus <i>Streptococcus</i> and FOS (ProLBS + FOS); and ProLB plus <i>Enterococcus</i> (ProLBE). We found that use of ProLBS with FOS in breast cancer patients and use of ProLBE in survivors of breast cancer show potential benefits in countering obesity and dyslipidemia. ProLBS with FOS use decreases pro-inflammatory TNF-α in breast cancer survivors and improves quality of life in those with breast-cancer-associated lymphedema. Supplementing probiotics capsules (10<sup>9</sup> CFU) with a prebiotic and using an intake duration of 10 weeks could provide a better approach than probiotics alone.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | breast cancer, probiotics, prebiotics, metabolites, cytokines |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Feb 2023 09:02 |
| Last Modified: | 22 Mar 2023 18:24 |
| DOI: | 10.3390/biology12020280 |
| Open Access URL: | https://www.mdpi.com/2079-7737/12/2/280 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3168334 |
Dimensions
Dimensions
