Price, Vivien 
ORCID: 0000-0003-3573-5106, Ngwira, Lucky Gift, Lewis, Joseph M ORCID: 0000-0002-3837-5188, Baker, Kate S ORCID: 0000-0001-5850-1949, Peacock, Sharon J, Jauneikaite, Elita and Feasey, Nicholas
(2023)
A systematic review of economic evaluations of whole-genome sequencing for the surveillance of bacterial pathogens.
Microbial genomics, 9 (2).
mgen000947-.
Abstract
Whole-genome sequencing (WGS) has unparalleled ability to distinguish between bacteria, with many public health applications. The generation and analysis of WGS data require significant financial investment. We describe a systematic review summarizing economic analyses of genomic surveillance of bacterial pathogens, reviewing the evidence for economic viability. The protocol was registered on PROSPERO (CRD42021289030). Six databases were searched on 8 November 2021 using terms related to 'WGS', 'population surveillance' and 'economic analysis'. Quality was assessed with the Drummond-Jefferson checklist. Following data extraction, a narrative synthesis approach was taken. Six hundred and eighty-one articles were identified, of which 49 proceeded to full-text screening, with 9 selected for inclusion. All had been published since 2019. Heterogeneity was high. Five studies assessed WGS for hospital surveillance and four analysed foodborne pathogens. Four were cost-benefit analyses, one was a cost-utility analysis, one was a cost-effectiveness analysis, one was a combined cost-effectiveness and cost-utility analysis, one combined cost-effectiveness and cost-benefit analyses and one was a partial analysis. All studies supported the use of WGS as a surveillance tool on economic grounds. The available evidence supports the use of WGS for pathogen surveillance but is limited by marked heterogeneity. Further work should include analysis relevant to low- and middle-income countries and should use real-world effectiveness data.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antimicrobial resistance, economic evaluation, foodborne pathogens, infection prevention and control, systematic review, whole-genome sequencing |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Mar 2023 10:23 |
| Last Modified: | 14 Mar 2024 18:00 |
| DOI: | 10.1099/mgen.0.000947 |
| Open Access URL: | https://www.microbiologyresearch.org/content/journ... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3168981 |
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